Test Code: 902652


Clinical Significance:

HLA-B*5701 has been shown in clinical studies to be associated with Abacavir hypersensitivity reaction (HSR) in HIV patients.1,2  In Abacavir-naïve patients, HLA-B*5701 genotyping may be useful for risk stratification.3


Specimen Requirements:

Preferred sample: 10 mL room temperature whole blood collected in yellow-top (ACD A or ACD B) tubes (5 mL minimum).

Alternate sample: Whole blood in EDTA lavender-top tubes is also acceptable.


CPT Codes*:

83891, 83896 x30, 83900, 83912 


Method:

Polymerase Chain Reaction (PCR) followed by hybridization with sequence specific oligonucleotide probes. 


Set-Up/Analytic Time:

Set-up Monday – Friday; reports within 8 days


FDA Status:

FDA approved/cleared


Additional Information:

Additional testing by sequence based typing (SBT) may be performed when necessary.


References

  1. Mallal S. et al. Lancet. 2002 Mar 2; 359 (9308):727-32
  2. Rauch A. et al. Clin. Inf. Dis. 2006 July; 43 (1):99-102
  3. Philips, E Clin. Inf. Dis. 2006 July; 43 (1):103-105

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

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